SOMATOSTATIN INHIBITS GASTRIN-INDUCED HISTAMINE-SECRETION AND SYNTHESIS IN THE RAT

被引：8

作者：

KONDO, S ^{[1
]}

SHINOMURA, Y ^{[1
]}

KANAYAMA, S ^{[1
]}

KAWABATA, S ^{[1
]}

MIYAZAKI, Y ^{[1
]}

IMAMURA, I ^{[1
]}

FUKUI, H ^{[1
]}

MATSUZAWA, Y ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT PHARMACOL 2,SUITA,OSAKA 565,JAPAN

来源：

REGULATORY PEPTIDES | 1993年 / 48卷 / 03期

关键词：

GASTRIC ACID SECRETION; HISTIDINE DECARBOXYLASE; HISTAMINE CONTENT; URINARY HISTAMINE EXCRETION;

D O I：

10.1016/0167-0115(93)90166-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Somatostatin is a potent inhibitor of gastric acid secretion. However, the effect of somatostatin on gastric histamine secretion and synthesis has not been well understood, despite the fact that histamine plays a key role in the regulation of gastric acid secretion. This study was designed to determine the effect of somatostatin on gastric histamine mobilization and acid secretion in conscious rats. In conscious rats with a gastric fistula, a 4 h intravenous infusion of gastrin-17 I (1 nmol/kg/h) evoked a marked increase in fundic histidine decarboxylase activity (the sole histamine-forming enzyme) and reduced fundic histamine content with a concomitant increase in gastric acid secretion. Somatostatin-14 (10 nmol/kg/h) significantly inhibited gastrin-induced gastric acid secretion and fundic histidine decarboxylase activity and prevented a gastrin-induced decrease in fundic histamine content. In conscious rats with a vesical fistula, somatostatin-14 (10 nmol/kg/h) significantly inhibited the urinary histamine excretion induced by a gastrin-17 I (1 nmol/kg/h) infusion. These findings suggest that the inhibitory action of somatostatin on gastrin-induced acid secretion is mediated by the inhibition of histamine mobilization.

引用

页码：373 / 380

页数：8

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