TACHYKININ RECEPTORS IN THE RAT ISOLATED UTERUS

被引：17

作者：

FISHER, L ^{[1
]}

PENNEFATHER, JN ^{[1
]}

HALL, S ^{[1
]}

机构：

[1] MONASH UNIV,DEPT PHARMACOL,CLAYTON,VIC 3168,AUSTRALIA

来源：

REGULATORY PEPTIDES | 1993年 / 46卷 / 1-2期

关键词：

NEUROKININ A; LYS5-MELEU9-NLE10]NKA (4-10); SR-48968; ENDOPEPTIDASE; 24.11; ESTROGEN; NK-2; RECEPTOR;

D O I：

10.1016/0167-0115(93)90098-S

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tachykinin receptors mediating uterotonic effects were examined in preparations from oestrogen-primed rats. In the absence of peptidase inhibitors [Lys5-MeLeu9-Nle10] NKA (4-10) was 14-fold more potent than neurokinin A (NKA), but the two peptides were equipotent in the presence of phosphoramidon alone and in combination with amastatin. The NK-2 receptor antagonist SR 48968 antagonised responses to the tachykinins. These findings indicate that an NK-2 receptor is present in the oestrogen-primed rat uterus and that endopeptidase 24.11 plays a major role to inactivate NKA in this tissue.

引用

页码：396 / 398

页数：3

共 8 条

[1]

CHAISSANG G, 1991, NEUROPEPTIDES, V19, P91

[2]

EMONDSALT X, 1992, NEUROPEPTIDES, V22, P21

[3]

FISHER L, 1993, REGUL PEPT, V46

[4] THE METABOLISM OF NEUROPEPTIDES - NEUROKININ-A (SUBSTANCE-K) IS A SUBSTRATE FOR ENDOPEPTIDASE-24.11 BUT NOT FOR PEPTIDYL DIPEPTIDASE-A (ANGIOTENSIN-CONVERTING ENZYME) [J].