OXYRADICAL-MEDIATED CHROMOSOME-DAMAGE IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

被引：8

作者：

EMERIT, I

ARUTYUNYAN, R

SARKISIAN, T

MEJLUMIAN, H

TOROSIAN, E

PANOSSIAN, AG

机构：

[1] STATE MED INST,DEPT PEDIAT,YEREVAN 25,ARMENIA

[2] STATE UNIV YEREVAN,DEPT GENET,YEREVAN 49,ARMENIA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1993年 / 15卷 / 03期

关键词：

OXYRADICALS; CHROMOSOME DAMAGE; FAMILIAL MEDITERRANEAN FEVER; FREE RADICALS;

D O I：

10.1016/0891-5849(93)90073-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Increased chromosome breakage is observed in patients with familial mediterranean fever (FMF). Their plasma contains clastogenic material inducing chromosome damage in cells from healthy persons. It is proposed that increased oxyradical generation by activated polymorphonuclear cells in blood and serosal fluids of these patients leads to the formation of a clastogenic factor (CF), as it is observed in other chronic inflammatory diseases. Also similar to these diseases, the clastogenic effects are prevented by superoxide dismutase and partially by inhibitors of arachidonic acid metabolism.

引用

页码：265 / 271

页数：7

共 29 条

[1] CIRCULATING HYDROXY FATTY-ACIDS IN FAMILIAL MEDITERRANEAN FEVER [J].