(R)-2,3-O-CYCLOHEXYLIDENEGLYCERALDEHYDE, A VERSATILE INTERMEDIATE FOR ASYMMETRIC-SYNTHESIS OF CHIRAL ALCOHOL

被引：109

作者：

CHATTOPADHYAY, A ^{[1
]}

MAMDAPUR, VR ^{[1
]}

机构：

[1] BHABHA ATOM RES CTR,DIV BIOORGAN,BOMBAY 400085,MAHARASHTRA,INDIA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 03期

关键词：

D O I：

10.1021/jo00108a020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Grignard addition to (R)-2,3-O-cyclohexylideneglyceraldehyde (IIa) gave rise to column chromatographically separable diastereo alcohols 2 and 3 including highly functionalized and synthetically exploitable homoallylic alcohols 2e and 3e and homopropargylic alcohols 2f and 3f. Compound 3c on functional manipulation gave rise to (-)-coriolic acid synthon 6.

引用

页码：585 / 587

页数：3

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