SEPTIDE BUT NOT SUBSTANCE-P STIMULATES INHIBITORY NEURONS IN GUINEA-PIG ILEUM

被引：18

作者：

BURCHER, E

STAMATAKOS, C

机构：

[1] School of Physiology and Pharmacology, University of New South Wales, Sydney

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 258卷 / 03期

基金：

英国医学研究理事会;

关键词：

TACHYKININ RECEPTOR; SEPTIDE; MYENTERIC PLEXUS;

D O I：

10.1016/0014-2999(94)90494-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent evidence suggests that [pGlu(6),Pro(9)]substance P-(6-11) (septide) may act on unusual tachykinin receptors. Here, we investigated the mechanisms of action of septide and other agonists acting on tachykinin NK, receptors, in the guinea-pig ileum. Responses to septide but not to substance P or [Sar(9),Met(O-2)(11)]substance P were significantly (P < 0.01) potentiated by 1 mu M tetrodotoxin. The data suggest that septide not only acts directly on smooth muscle tachykinin receptors to produce contraction, but also stimulates another receptor subtype on myenteric neurons to release inhibitory substance(s).

引用

页码：R9 / R10

页数：2

共 8 条

[1] COMPARISON IN DIFFERENT TISSUE PREPARATIONS OF THE INVITRO PHARMACOLOGICAL PROFILE OF RP 67580, A NEW NONPEPTIDE SUBSTANCE-P ANTAGONIST [J].