KINETICS OF DRUG TRANSPORT AND CONCURRENT METABOLISM IN HUMAN CELL-CULTURES .1. THEORY

被引：1

作者：

ANDO, HY ^{[1
]}

HO, NFH ^{[1
]}

HIGUCHI, WI ^{[1
]}

SHIPMAN, C ^{[1
]}

机构：

[1] UNIV MICHIGAN,COLL PHARM,ANN ARBOR,MI 48104

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1978年 / 67卷 / 05期

关键词：

Drug transport kinetics—evaluated in suspension cultures of mammalian cells; equations derived; Kinetics—drug transport and concurrent metabolism in suspension cultures of mammalian cells; Metabolism; single step—evaluated for drugs in suspension cultures of mammalian cells;

D O I：

10.1002/jps.2600670508

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A method for evaluating the passive permeability and single‐step metabolism of drugs in suspension cultures of mammalian cells was formulated assuming linear kinetics. It was assumed that the metabolizing enzymes are driven by endogenous substrates present in steady‐state quantities. The presence of the drug in radiolabeled tracer quantities was assumed to cause only a small perturbation from the endogenous steady‐state operating point. The time course solutions for the drug and its metabolite are given in terms of macroscopic constants, and their physical interpretations are given in terms of metabolic and transport parameters. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company

引用

页码：606 / 610

页数：5

共 17 条

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