EPIDEMIOLOGY OF ADENOCARCINOMAS OF THE SMALL-INTESTINE - IS BILE A SMALL-BOWEL CARCINOGEN

被引:99
作者
ROSS, RK [1 ]
HARTNETT, NM [1 ]
BERNSTEIN, L [1 ]
HENDERSON, BE [1 ]
机构
[1] UNIV SO CALIF, SCH MED, KENNETH NORRIS JR COMPREHENS CANC CTR, LOS ANGELES, CA 90033 USA
关键词
D O I
10.1038/bjc.1991.29
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Using pathology reports and other data from the Cancer Surveillance Program, the population-based cancer registry of Los Angeles County, we evaluated demographic characteristics and the detailed subsite distribution of adenocarcinomas of the small intestine for the period 1972-1985. The most striking finding was the great preponderance of these tumours in the duodenum, especially in comparison with other histologic types of small bowel cancer. Fifty percent of all small intestinal adenocarcinomas occurred at this location, even though the duodenum comprises just 4% of the entire length of the small bowel. Furthermore, after excluding those cases occurring in the duodenum but with indeterminate subsite, 57% of these duodenal primaries could be mapped to the 2nd portion of the duodenum, a six to seven centimeter segment containing the Ampulla of Vater. We could pinpoint the location for 48 of the 77 tumours (62%) occurring in this segment, specifically to areas adjacent to the Ampulla. We also confirmed the high male to female ratio of small bowel adenocarcinomas in blacks and non-Latino whites, but could find no evidence of such an effect in Latinos or Asians; however, the number of cases was not large in these latter two racial-ethnic groups.
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页码:143 / 145
页数:3
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