WITTIG OLEFINATION IN THE ABSENCE OF AN EXOGENOUS BASE - A NEW SYNTHESIS OF ALPHA-SUBSTITUTED PRIMARY ALLYLIC AMINES

被引：11

作者：

DELLARIA, JF

SALLIN, KJ

机构：

[1] Immunosciences Research Area, Department 47K, Abbott Laboratories, Abbott Park

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)94666-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of α-substituted primary allylic amines through the in situ generation and trapping of an ylide from the reaction of an N-acyl aziridine, triphenylphosphine, and an aldehyde in refluxing isopropanol is reported. These compounds can be prepared enantioselectively (>94.6% ee) by employing a chiral nonracemic N-acyl aziridine. © 1990.

引用

页码：2661 / 2664

页数：4

共 24 条

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