COPPER ELECTRON-TRANSFER INDUCED TRIFLUOROMETHYLATION WITH METHYL FLUOROSULPHONYLDIFLUOROACETATE

被引:22
作者
CHEN, QY
YANG, GY
WU, SW
机构
[1] Shanghai Institute of Organic Chemistry, Academia Sinica, Shanghai, 200032
基金
中国国家自然科学基金;
关键词
D O I
10.1016/S0022-1139(00)82357-X
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Treatment of halogen compounds, RX, with methyl fluorosulfonyldifluoroacetate and copper powder in dimethylformamide for 4 h at 65-80-degrees-C resulted in the corresponding trifluoromethylated products, RCF3, in good yield. In the absence of halogen compounds and at 100-degrees-C, methyl triflone (CF3SO2CH3) was synthesized readily in 20-30% yield from the same reaction system. The fact that the reaction was suppressed by oxygen, p-dinitrobenzene or in darkness suggested that a copper-induced electron-transfer process was involved in this new trifluoromethylating system.
引用
收藏
页码:291 / 298
页数:8
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