JUMPING TRANSLOCATION IN A 17-MONTH-OLD CHILD WITH MIXED-LINEAGE LEUKEMIA

被引：26

作者：

BENNERIAH, S

ABRAMOV, A

LERER, I

POLLIACK, A

LEIZEROWITZ, R

RABINOWITZ, R

ABELIOVICH, D

机构：

[1] HADASSAH UNIV HOSP,DEPT HUMAN GENET,KIRYAT HADASSAH POB 12000,IL-91120 JERUSALEM,ISRAEL

[2] HADASSAH UNIV HOSP,DEPT HEMATOL,LYMPHOMA LEUKEMIA UNIT,IL-91120 JERUSALEM,ISRAEL

[3] SHAARE ZEDEK MED CTR,DEPT PEDIAT,IL-91000 JERUSALEM,ISRAEL

[4] HEBREW UNIV JERUSALEM,HADASSAH UNIV MED CTR,HUBERT H HUMPHREY CTR EXPTL MED & CANC RES,JERUSALEM,ISRAEL

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 56卷 / 02期

关键词：

D O I：

10.1016/0165-4608(91)90174-S

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 17-month-old child with acute biphenotypic (pre B-ALL/myelomonocytic) leukemia is reported. Extensive cytogenetic analysis performed at various stages of the disease revealed a clonal evolution at the time of initial diagnosis with two types of abnormal clones, one with trisomy 22 and two other related clones with trisomy 22 plus partial trisomy of the long arm of chromosome 1 associated with the telomeric segment of either chromosome 20q or 21p. At the time of relapse the only abnormal clone involved trisomy 22 and partial trisomy of 1q, but this time in association with the telomeric segment of 14p. The unique feature of these translocations is discussed and the possibility of the correlation between the different chromosomal abnormalities and the expression of biphenotypic markers is raised.

引用

页码：223 / 229

页数：7

共 21 条

[1] MIXED LINEAGE LEUKEMIA WITH CYTOGENETICALLY UNRELATED ABNORMAL CLONES [J].