TOTAL SYNTHESIS OF THE CYTOTOXIC MACROCYCLE (+)-HITACHIMYCIN

被引：52

作者：

SMITH, AB ^{[1
]}

RANO, TA ^{[1
]}

CHIDA, N ^{[1
]}

SULIKOWSKI, GA ^{[1
]}

WOOD, JL ^{[1
]}

机构：

[1] UNIV PENN,RES STRUCT MATTER LAB,PHILADELPHIA,PA 19104

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 21期

关键词：

D O I：

10.1021/ja00047a008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first total synthesis of the antitumor antibiotic (+)-hitachimycin (a.k.a. stubomycin) (1) has been achieved in 22 steps and 1.1% overall yield. The cornerstone of the synthetic strategy was a highly stereoselective three-component coupling of (-)-5-methoxycyclopentenone (4) with a zincate derived from vinyl iodide 3a and aldehyde (-)-51.

引用

页码：8008 / 8022

页数：15

共 48 条

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