MARKED PARENTAL CONSANGUINITY AS A CAUSE FOR INCREASED MAJOR MALFORMATIONS IN AN ISRAELI ARAB COMMUNITY

被引:86
作者
JABER, L
MERLOB, P
BU, XD
ROTTER, JI
SHOHAT, M
机构
[1] BEILINSON MED CTR, FELSENSTEIN RES INST, DEPT MED GENET, IL-49100 PETAH TIQWA, ISRAEL
[2] TEL AVIV UNIV, SACKLER SCH MED, TEL AVIV, ISRAEL
[3] CEDARS SINAI MED CTR, CTR MED GENET BIRTH DEFECTS, LOS ANGELES, CA 90048 USA
[4] UNIV CALIF LOS ANGELES, SCH MED, LOS ANGELES, CA 90024 USA
[5] BEILINSON MED CTR, FELSENSTEIN RES INST, DEPT PEDIAT, IL-49100 PETAH TIQWA, ISRAEL
[6] BEILINSON MED CTR, FELSENSTEIN RES INST, DEPT NEONATOL, IL-49100 PETAH TIQWA, ISRAEL
来源
AMERICAN JOURNAL OF MEDICAL GENETICS | 1992年 / 44卷 / 01期
关键词
MAJOR MALFORMATIONS; CONSANGUINITY; FOUNDER EFFECT;
D O I
10.1002/ajmg.1320440102
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
It is common among Israeli Arabs who live in the villages to prefer consanguineous marriages, particularly among first cousins. In addition, such villages are populated by a few (< 20) original families, and inter-family/intervillage marriages are infrequent. The purpose of this study was to examine the consequences of such "consanguinity" in Taibe, a large Arab village, 30 km from Tel Aviv. Six hundred ten families were prospectively ascertained through infants who were routinely seen in the local "Well Baby Clinics." A significant increase in the incidence of major malformations was noted in relation to the closeness of the parental relationship. For the index cases group the prevalence of individuals with major malformations were 5.8% in the product of inter-village marriages, 8.3% in the intra-village non-related matings, 15.1% in the distant consanguineous group, and up to 15.8% in the progeny of first-cousin marriages (P < 0.001). In the siblings of these index cases, the frequency of major malformations was 4.3%, 4.5%, 10.5%, and 10.3%, respectively. Analysis of the major malformations by each body system showed the same trend. The study demonstrates a marked high rate of consanguineous marriages, whose effect leads to a marked increase in major malformations and thus a prominent public health problem in such villages. This requires a unique genetic counseling approach.
引用
收藏
页码:1 / 6
页数:6
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