MEMBRANE STABILIZING PROPERTIES OF THE SELECTIVE 5-HT2 RECEPTOR AGONIST, (+/-)-DOI

被引：3

作者：

MARTIN, KF

KELLETT, R

BUCKETT, WR

机构：

[1] Boots Pharmaceuticals Research Department, Nottingham

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 200卷 / 01期

关键词：

DOI (1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE); MEMBRANE STABILIZATION; SCIATIC NERVE (FROG);

D O I：

10.1016/0014-2999(91)90687-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a selective 5-HT2 receptor agonist, on nerve conduction in the isolated frog sciatic nerve trunk were examined. Compound action potential amplitude was concentration dependently decreased by (+/-)-DOI (EC50 = 1.2 mM), an effect that was not altered by the presence of ketanserin and with a similar potency to lignocaine, (+/-)-propranolol and disopyramide. The results indicate that (+/-)-DOI has membrane stabilising properties, in addition to its reported 5-HT2 agonist actions.

引用

页码：191 / 193

页数：3

共 10 条

[1] QUANTIFICATION OF NORADRENALINE IONTOPHORESIS [J].