ANTIMALARIAL COMPOUNDS FROM HOSLUNDIA-OPPOSITA

被引：61

作者：

ACHENBACH, H ^{[1
]}

WAIBEL, R ^{[1
]}

NKUNYA, MHH ^{[1
]}

WEENEN, H ^{[1
]}

机构：

[1] UNIV DAR ES SALAAM, DEPT CHEM, DAR ES SALAAM, TANZANIA

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 11期

关键词：

HOSLUNDIA-OPPOSITA VAHL; LAMIACEAE; 3-O-BENZOYLHOSLOPPONE; 3-O-CINNAMOYLHOSLOPPONE; 3-O-BENZOYLHINOKIOL; 3-O-BENZOYLHOSLOQUINONE; ANTIMALARIAL ACTIVITY;

D O I：

10.1016/S0031-9422(00)97526-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new abietane-type esters, 3-O-benzoylhosloppone, 3-O-cinnamoylhosloppone, 3-O-benzoylhinokiol and 3-O-benzoylhosloquinone were isolated from the root bark of the antimalarial plant Hoslundia opposita Vahl. and their structures were determined by a combination of spectroscopic methods and chemical correlations. 3-O-Benzoylhosloppone inhibits the growth of the multidrug resistant strain K1 of Plasmodium falciparum in vitro with an IC50-value of 0.4 mug ml-1.

引用

页码：3781 / 3784

页数：4

共 17 条

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