IDENTIFICATION AND SYNTHESIS OF A METABOLITE OF KH 1060, A NEW POTENT 1-ALPHA,25-DIHYDROXYVITAMIN-D3 ANALOG

被引：3

作者：

ANDERSEN, NR

BUCHWALD, FA

GRUESORENSEN, G

机构：

[1] LEO PHARMACEUT PROD,DEPT SPECTR,DK-2750 BALLERUP,DENMARK

[2] LEO PHARMACEUT,CHEM RES DEPT,DK-2750 BALLERUP,DENMARK

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80462-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A metabolite (2) from pig liver of a potent analogue (KH 1060, 1) of la,25-dihydroxyvitamin D3 is identified by spectroscopy and chemical synthesis starting from (S)-malic acid.

引用

页码：1713 / 1716

页数：4

共 5 条

[1] 20-EPI-VITAMIN-D3 ANALOGS - A NOVEL CLASS OF POTENT REGULATORS OF CELL-GROWTH AND IMMUNE-RESPONSES
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LATINI, S
BINDERUP, E
BRETTING, C
CALVERLEY, M
HANSEN, K
[J]. BIOCHEMICAL PHARMACOLOGY, 1991, 42 (08) : 1569 - 1575
[2] HANSEN K, 1991, VITAMIN D, P161
[3] JONES G, 1987, Steroids, V49, P29, DOI 10.1016/0039-128X(87)90078-X
[4] KISSMEYER AM, UNPUB XENOBIOTICA
[5] USE OF MALIC-ACID AS A CHIRAL SYNTHON - 24,25-DIHYDROXYCHOLECALCIFEROL
STERLING, J
SLOVIN, E
BARASCH, D
[J]. TETRAHEDRON LETTERS, 1987, 28 (15) : 1685 - 1688

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