INDUCTION OF CYTOCHROME-P450 2E1 DURING CHRONIC ETHANOL EXPOSURE OCCURS VIA TRANSCRIPTION OF THE CYP 2E1 GENE WHEN BLOOD-ALCOHOL CONCENTRATIONS ARE HIGH

被引：98

作者：

BADGER, TM ^{[1
]}

HUANG, J ^{[1
]}

RONIS, M ^{[1
]}

LUMPKIN, CK ^{[1
]}

机构：

[1] ARKANSAS CHILDRENS HOSP,RES CTR,LITTLE ROCK,AR 72205

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 190卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induction of cytochrome P450 CYP 2E1 during chronic ethanol exposure in rats has been reported by our laboratory to occur by a complex two step process. The first step occurs at relatively low blood alcohol concentrations and involves increases in CYP 2E1-dependent activities and apoprotein levels with no increases in steady-state mRNA encoding CYP 2E1. The second step of this process occurs at higher blood alcohol concentrations and involves elevated mRNA levels. In this report, we demonstrate for the first time that CYP 2E1 induction by chronic ethanol is associated with increased CYP 2E1 gene transcription and is independent of gonadal factors. © 1993 Academic Press, Inc.

引用

页码：780 / 785

页数：6

共 12 条

[1]

BADGER TM, 1993, IN PRESS J PHARM EXP

[2] ETHANOL INTERFERES WITH REGENERATION-ASSOCIATED CHANGES IN BIOTRANSFORMING ENZYMES - A POTENTIAL MECHANISM UNDERLYING ETHANOLS CARCINOGENICITY [J].