EMERGENCY ADMISSIONS OF OPIOID DRUG-ABUSERS FOR OVERDOSE - A CHRONOBIOLOGICAL STUDY OF ENHANCED RISK

被引：22

作者：

MANFREDINI, R

GALLERANI, M

CALO, G

PASIN, M

GOVONI, M

FERSINI, C

机构：

来源：

ANNALS OF EMERGENCY MEDICINE | 1994年 / 24卷 / 04期

关键词：

D O I：

10.1016/S0196-0644(94)70270-5

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

Study objective: To determine whether there is a specific temporal risk for opioid drug overdose. Design: To study patients presenting to the ED in a comatose state from accidental drug opioid overdose. Participants: Two hundred seventy-four patients were admitted to the ED of the Hospital of Ferrara, Italy, from 1988 to 1990, 225 men (82.1%; mean age, 25+/-3.4 years) and 49 women (17.9%; mean age, 23.5+/-2.8 years). Interventions: Month, day, and hour and minute of admissions were recorded, and time-qualified frequency data were analyzed by the single cosinor method. Results: Cosinor analysis demonstrated a significant circadian rhythm for both the total number of observations and the separate male and female subgroups with an early evening peak (''acrophase'') at about 7:00 PM. No significant circannual rhythm was evident, but for the total group a significant 6-month rhythm was demonstrable with peaks in late November and late May. Conclusion: There is a distinct ''chronorisk'' of opioid drug overdose in the early evening hours.

引用

页码：615 / 618

页数：4

共 8 条

[1]

Tarquini, Benvenuti, Moretti, Et al., Atherosclerotic chronorisk recognized by autorhythmometry combined with hemopsies has a step toward chronoprophylaxis, Chronobiologia, 6, pp. 162-163, (1979)

[2]

Muller, Stone, Turi, Et al., Circadian variation in the frequency of onset of acute myocardial infarction, N Engl J Med, 313, pp. 1315-1322, (1985)

[3]

Muller, Ludmer, Willich, Et al., Circadian variation in the frequency of sudden cardiac death, Circulation, 75, pp. 131-138, (1987)

[4]

Gallerani, Manfredini, Ricci, Et al., Sudden death from pulmonary thromboembolism: Chronobiological aspects, Eur Heart J, 13, pp. 661-665, (1992)

[5]

Marler, Price, Clark, Et al., Morning increase in onset of ischemic stroke, Stroke, 20, pp. 473-476, (1989)

[6]

Nelson, Tong, Lee, Et al., Methods for cosinor-rhythmometry, Chronobiologia, 6, pp. 305-323, (1979)

[7]

Morris, Circadian and circannual rhythms of emergency room drug overdose admissions, Advances in Chronobiology, part B, pp. 451-457, (1987)

[8]

Morris, Dosing drugs by the circadian clock, Pharmindex, 28, pp. 7-15, (1986)

← 1 →