NEUROTENSIN EXCITES BASAL FOREBRAIN CHOLINERGIC NEURONS - IONIC AND SIGNAL-TRANSDUCTION MECHANISMS

被引：58

作者：

FARKAS, RH ^{[1
]}

NAKAJIMA, S ^{[1
]}

NAKAJIMA, Y ^{[1
]}

机构：

[1] UNIV ILLINOIS, COLL MED, DEPT PHARMACOL, CHICAGO, IL 60612 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 07期

关键词：

ELECTROPHYSIOLOGY; G-PROTEIN; PERTUSSIS TOXIN; INWARD RECTIFICATION; CELL CULTURE;

D O I：

10.1073/pnas.91.7.2853

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The whole-cell patch-damp technique was used to investigate the effect of neurotensin on cholinergic neurons cultured from the rat nucleus basalis of Meynert. Neurotensin excited the neurons by inducing an initial inward current carried, at least in part, by Na+ and by reducing inwardly rectifying K+ conductance. Reduction of the inwardly rectifying K+ conductance was mediated by a pertussis toxinin-sensitive G protein.

引用

页码：2853 / 2857

页数：5

共 44 条

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