ABSENCE OF ANDROGEN RECEPTORS IN LHRH IMMUNOREACTIVE NEURONS

被引：88

作者：

HUANG, XP

HARLAN, RE

机构：

[1] TULANE UNIV, SCH MED, DEPT ANAT, 1430 TULANE AVE, NEW ORLEANS, LA 70112 USA

[2] TULANE UNIV, SCH MED, NEUROSCI TRAINING PROGRAM, NEW ORLEANS, LA 70112 USA

来源：

BRAIN RESEARCH | 1993年 / 624卷 / 1-2期

关键词：

STEROID HORMONE RECEPTOR; ANDROGEN; IMMUNOREACTIVITY; HYPOTHALAMUS; RAT;

D O I：

10.1016/0006-8993(93)90094-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Androgen has a negative feedback effect upon reproductive functions. Studies have suggested that this effect is mediated partially at the hypothalamic level. However, it is not clear whether the action is direct or indirect on LHRH neurons. In the present study, double immunocytochemistry was used to localize LHRH and androgen receptors. Out of 5892 LHRH immunoreactive neurons, no double-labelled neurons were observed. We conclude that the feedback effect of androgen on the central nervous system is mediated by indirect pathway(s).

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页码：309 / 311

页数：3

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