INCREASED SUSCEPTIBILITY TO OXIDATION OF LOW-DENSITY LIPOPROTEINS ISOLATED FROM PATIENTS WITH SYSTEMIC-SCLEROSIS

被引：72

作者：

BRUCKDORFER, KR ^{[1
]}

HILLARY, JB ^{[1
]}

BUNCE, T ^{[1
]}

VANCHEESWARAN, R ^{[1
]}

BLACK, CM ^{[1
]}

机构：

[1] ROYAL FREE HOSP, SCH MED, DEPT RHEUMATOL, LONDON NW3 2PF, ENGLAND

来源：

ARTHRITIS AND RHEUMATISM | 1995年 / 38卷 / 08期

关键词：

D O I：

10.1002/art.1780380807

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To examine the resistance to oxidation of low-density lipoproteins (LDL) from patients with systemic sclerosis (SSc) and primary Raynaud's phenomenon (RP) compared with healthy controls, Methods. Plasma LDL were isolated from patients with diffuse cutaneous and limited cutaneous SSc (dcSSc and IcSSc, respectively), patients with primary RP, and healthy control subjects, The lipoproteins were assessed for their resistance to oxidation in the presence of cupric ions, using spectrophotometric assays. Results. LDL from patients with dcSSc and IcSSc were more susceptible to oxidation than were those from healthy control subjects or patients with RP, Conclusion. Our findings suggest that free radicals may play a role in the pathology of SSc.

引用

页码：1060 / 1067

页数：8

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