SUPPRESSION OF PHAGOCYTOSIS BY ADRENOCORTICOTROPIC HORMONE IN MURINE PERITONEAL-MACROPHAGES

被引：13

作者：

ICHINOSE, M

SAWADA, M

MAENO, T

机构：

[1] Department of Physiology, Shimane Medical University, Izumo

来源：

IMMUNOLOGY LETTERS | 1994年 / 42卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

ADRENOCORTICOTROPIC HORMONE; MACROPHAGE; PHAGOCYTOSIS; FLOW CYTOMETRY;

D O I：

10.1016/0165-2478(94)90080-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Phagocytosis of latex beads by peritoneal macrophages was examined by means of flow cytometry (FCM). This assay revealed that adrenocorticotropic hormone (ACTH) suppressed phagocytosis in a dose-dependent manner. ACTH (1-24) was more suppressive than ACTH (1-39). Control phagocytosis was partially suppressed in Ca2+-free solution. Phagocytosis was suppressed by ACTH in this solution to the same degree as in the normal solution. Suppression by ACTH was reduced in phosphodiesterase inhibitor-containing solution. These results suggest that (1) ACTH suppresses extracellular Ca2+-dependent and -independent phagocytosis, (2) the suppression is not mediated by cAMP and (3) the inhibition of macrophage phagocytosis by ACTH is one of the mechanisms that modulate immune responses in stressful situations.

引用

页码：161 / 165

页数：5

共 24 条

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