DENATURATION OF CYTOCHROME-P-450 BY INDOMETHACIN AND OTHER NONSTEROIDAL ANTIINFLAMMATORY DRUGS - EVIDENCE FOR A SURFACTANT MECHANISM AND A SELECTIVE EFFECT OF A PARA-CHLOROPHENYL MOIETY

被引:11
作者
FALZON, M [1 ]
NIELSCH, A [1 ]
BURKE, MD [1 ]
机构
[1] UNIV ABERDEEN MARISCHAL COLL,DEPT PHARMACOL,ABERDEEN AB9 1AS,SCOTLAND
关键词
D O I
10.1016/0006-2952(86)90021-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:4019 / 4024
页数:6
相关论文
共 30 条
[1]  
BELLANGER PM, 1985, CAN J PHYSL PHARM, V63, P798
[2]   THE DESTRUCTION OF CYTOCHROME-P-450 BY ALCLOFENAC - POSSIBLE INVOLVEMENT OF AN EPOXIDE METABOLITE [J].
BROWN, LM ;
FORDHUTCHINSON, AW .
BIOCHEMICAL PHARMACOLOGY, 1982, 31 (02) :195-199
[3]  
Buege J A, 1978, Methods Enzymol, V52, P302
[4]   DECREASED HEPATIC-MICROSOMAL CYTOCHROME-P450 DUE TO INDOMETHACIN - PROTECTIVE ROLES OF 16,16-DIMETHYLPROSTAGLANDIN-F2-ALPHA AND INDUCING AGENTS [J].
BURKE, MD ;
FALZON, M ;
MILTON, AS .
BIOCHEMICAL PHARMACOLOGY, 1983, 32 (03) :389-397
[5]   ADVERSE REACTIONS TO NON-STEROIDAL ANTIRHEUMATIC DRUGS [J].
CUTHBERT, MF .
CURRENT MEDICAL RESEARCH AND OPINION, 1974, 2 (09) :600-610
[6]   CONTINUOUS FLUOROMETRIC ASSAY OF EPOXIDE HYDRASE ACTIVITY [J].
DANSETTE, PM ;
DUBOIS, GC ;
JERINA, DM .
ANALYTICAL BIOCHEMISTRY, 1979, 97 (02) :340-345
[7]  
DEMONTELLANO PRO, 1983, ANNU REV PHARMACOL, V23, P481
[8]   CLINICAL PHARMACOLOGISTS VIEW OF DRUG HEPATOTOXICITY [J].
DUJOVNE, CA .
PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1977, 9 (01) :1-15
[9]   LIVER-CELL CULTURE TOXICITY AND SURFACTANT POTENCY OF ERYTHROMYCIN DERIVATIVES [J].
DUJOVNE, CA .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1975, 32 (01) :11-20
[10]   NEW TABLES FOR MULTIPLE COMPARISONS WITH CONTROL [J].
DUNNETT, CW .
BIOMETRICS, 1964, 20 (03) :482-&