CLINICAL OBSERVATIONS ON THE NEUROMUSCULAR BLOCKING ACTION OF ORG-9426, A NEW STEROIDAL NONDEPOLARIZING AGENT

被引：133

作者：

WIERDA, JMKH ^{[1
]}

DEWIT, APM ^{[1
]}

KUIZENGA, K ^{[1
]}

AGOSTON, S ^{[1
]}

机构：

[1] UNIV GRONINGEN,INST CLIN PHARMACOL,RES GRP,9713 EZ GRONINGEN,NETHERLANDS

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1990年 / 64卷 / 04期

关键词：

Intubation; tracheal; Neuromuscular relaxants: Org 9426; vecuronium;

D O I：

10.1093/bja/64.4.521

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Summary: The neuromuscular blocking effects of Org 9426, the 2-morpholino, 16-allyl-pyrrolidino derivative of the 3-desacetoxy analogue of vecuronium have been investigated in anaesthetized patients. Based on data from a pilot study, two doses, 250 and 500 μg kg-1 (estimated as the ED90 and 2 × ED 90, respectively) were chosen. Org 9426 appeared to be six to eight times less potent than vecuronium and showed a faster rate of development of neuromuscular block, with good to excellent intubation conditions within 60 s after administration of a dose of 500 μg kg-1. The duration of action and the recovery index appeared to be similar to those of vecuronium. Side effects were not noted. Org 9426 may have advantages over existing non-depolarizing neuromuscular blocking agents with respect to rate of development of good intubating conditions, and is stable in aqueous solutions. © 1990 British Journal of Anaesthesia.

引用

页码：521 / 523

页数：3

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