PROLACTIN-RELEASE BY INTRAVENOUS CIMETIDINE IN MAN - EVIDENCE FOR A SUPRAPITUITARY LOCUS OF ACTION

被引：30

作者：

FERRARI, C

CALDARA, R

BARBIERI, C

CAMBIELLI, M

BIERTI, L

ROMUSSI, M

机构：

[1] UNIV MILAN,MED 3 CLIN,I-20133 MILAN,ITALY

[2] FATEBENEFRATELLI HOSP,DEPT NUCL MED,MILAN,ITALY

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 11卷 / 06期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb03116.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In an attempt to identify the sites at which cimetidine stimulates prolactin release, the drug was administered intravenously (6 mg/kg body weight) to healthy subjects under basal conditions, during dopamine infusion (1/μg/Kg‐min for 120 min) and after pretreatment with L‐dopa plus carbidopa (250 plus 25 mg every 6 h for 1 day). The serum prolactin response to cimetidine was abolished by dopamine infusion and almost completely suppressed by L‐dopa plus carbidopa administration. These findings suggest that the drug acts on the central nervous system to stimulate prolactin release. Although the mechanism of this action is unclear, it does not seem to depend on an antidopaminergic effect and may be related to blockade of brain H2 histamine receptors. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：619 / 623

页数：5

共 19 条

[1] H-1 AND H-2 HISTAMINE RECEPTOR PARTICIPATION IN BRAIN CONTROL OF PROLACTIN SECRETION IN LACTATING RATS [J].