MORPHOLOGICAL TRANSFORMATION OF MICROGLIA INVITRO

被引：140

作者：

SUZUMURA, A ^{[1
]}

MARUNOUCHI, T ^{[1
]}

YAMAMOTO, H ^{[1
]}

机构：

[1] FUJITA HLTH UNIV, INST COMPREHENS MED SCI, DIV CELL BIOL, TOYOAKE, AICHI 47011, JAPAN

来源：

BRAIN RESEARCH | 1991年 / 545卷 / 1-2期

关键词：

MICROGLIA; CYTOKINE; MORPHOLOGICAL TRANSFORMATION; PROLIFERATION; ASTROCYTE;

D O I：

10.1016/0006-8993(91)91302-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Isolated microglia underwent in vitro morphological transformation to ameboid, rod-shaped and ramified forms in response to several cytokines, factors from astrocytes, or factors which affect macrophage function. These morphological transformations were reversible. Examination of the enzymatic activity, superoxide anion formation and proliferative activity of these transformed microglia indicated that the ameboid forms were activated, rod-shaped microglia were proliferating, and the ramified forms were resting microglia.

引用

页码：301 / 306

页数：6

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