BIOLOGICAL AND CHEMICAL STUDIES OF PERA-BENENSIS, A BOLIVIAN PLANT USED IN FOLK MEDICINE AS A TREATMENT OF CUTANEOUS LEISHMANIASIS

被引:73
作者
FOURNET, A
ANGELO, A
MUNOZ, V
ROBLOT, F
HOCQUEMILLER, R
CAVE, A
机构
[1] ORSTOM, INST FRANCAIS RECH SCI DEV COOPERAT, DEPT SANTE, F-75480 PARIS 10, FRANCE
[2] INST BOLIVIANO TECHNOL AGROPECUARIA, LA PAZ, BOLIVIA
关键词
CHIMANE INDIANS; FOLK MEDICINE; CUTANEOUS LEISHMANIASIS; PERA-BENENSIS; EUPHORBIACEAE; LEISHMANIA SP; TRYPANOSOMA-CRUZI; NAPHTHOQUINONES;
D O I
10.1016/0378-8741(92)90074-2
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The stem barks of Pera benensis are employed by the Chimane Indians in the Bolivian Amazonia as treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. The chloroform extracts containing quinones were found active against the promastigote forms of Leishmania and the epimastigote forms of Trypanosoma cruzi at 10-mug nl-1. The activity guided fractionation of the extract by chromatography afforded active compounds. Their structures were elucidated, by spectral and chemical studies, as known naphthoquinones, plumbagin, 3,3'-biplumbagin, 8-8'-biplumbagin, and triterpene, lupeol. The activity in vitro of each compound was evaluated against 5 strains of Leishmania (promastigote), 6 strains of Trypanosoma cruzi (epimastigote) and the intracellular form (amastigote) of Leishmania amazonensis. The baseline drugs used were Glucantime and pentamidine (Leishmania spp.), nifurtimox and benznidazole (T. cruzi). Plumbagin was the most active compound in vitro. This study has demonstrated that Pera benensis, a medicinal plant used in folk medicine, is an efficient treatment of cutaneous leishmaniasis.
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页码:159 / 164
页数:6
相关论文
共 14 条
[1]  
BERMAN JD, 1988, REV INFECT DIS, V10, P560
[2]  
CARVALHO LH, 1988, BRAZ J MED BIOL RES, V21, P485
[3]   THE ACTIVITY OF PLUMBAGIN AND OTHER ELECTRON CARRIERS AGAINST LEISHMANIA-DONOVANI AND LEISHMANIA-MEXICANA-AMAZONENSIS [J].
CROFT, SL ;
EVANS, AT ;
NEAL, RA .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1985, 79 (06) :651-653
[4]  
DEARIAS AR, 1990, 7EME C INT PAR PAR
[5]  
Docampo R., 1984, Free radicals in biology. Volume VI., P243
[6]  
Evans D.A., 1987, P52
[7]   EVALUATION OF THE TOXICITY OF 3-ALLYL-BETA-LAPACHONE AGAINST TRYPANOSOMA-CRUZI BLOOD-STREAM FORMS [J].
GONCALVES, AM ;
VASCONCELLOS, ME ;
DOCAMPO, R ;
CRUZ, FS ;
DESOUZA, W ;
LEON, W .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1980, 1 (03) :167-176
[8]  
GUJAR G T, 1990, Fitoterapia, V61, P387
[9]   ANTIPROTOZOAL ACTIVITY OF DIOSPYRIN TOWARDS LEISHMANIA-DONOVANI PROMASTIGOTES INVITRO [J].
HAZRA, B ;
SAHA, AK ;
RAY, R ;
ROY, DK ;
SUR, P ;
BANERJEE, A .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1987, 81 (05) :738-741
[10]   AN INVITRO SYSTEM FOR DETERMINING THE ACTIVITY OF COMPOUNDS AGAINST THE INTRACELLULAR AMASTIGOTE FORM OF LEISHMANIA-DONOVANI [J].
NEAL, RA ;
CROFT, SL .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1984, 14 (05) :463-475