THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE-II IN COMPLEX WITH BROMIDE AND AZIDE

被引：70

作者：

JONSSON, BM ^{[1
]}

HAKANSSON, K ^{[1
]}

LILJAS, A ^{[1
]}

机构：

[1] UNIV LUND,CTR CHEM,DEPT MOLEC BIOPHYS,BOX 124,S-22100 LUND,SWEDEN

来源：

FEBS LETTERS | 1993年 / 322卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

CARBONIC ANHYDRASE; X-RAY STRUCTURE; INHIBITOR; AZIDE; BROMIDE;

D O I：

10.1016/0014-5793(93)81565-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The three-dimensional structure of human carbonic anhydrase II complexed with azide and with bromide was investigated crystallographically. Both of these non-protonated inhibitors replace the zinc and the 'deep' water, two catalytically important water molecules in the active site of the molecule. Both the azide and the bromide ions bind in a distorted tetrahedral manner 0.4 and 1.1 angstrom from the zinc water position, respectively, but are in close contact (2.0 and 2.6 angstrom, respectively) with the zinc ion.

引用

页码：186 / 190

页数：5

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