BIG ENDOTHELIN-3-INDUCED HYPERTENSION AND ITS INHIBITION BY PHOSPHORAMIDON IN ANESTHETIZED RATS

被引：11

作者：

MATSUMURA, Y ^{[1
]}

FUJITA, K ^{[1
]}

TAKAOKA, M ^{[1
]}

MORIMOTO, S ^{[1
]}

机构：

[1] OSAKA UNIV PHARMACEUT SCI,DEPT PHARMACOL,2-10-65 KAWAI,MATSUBARA,OSAKA 580,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 230卷 / 01期

关键词：

ENDOTHELIN-3; BIG ENDOTHELIN-3; HYPERTENSIVE EFFECT; PHOSPHORAMIDON; METALLOPROTEINASE; (CONVERSION);

D O I：

10.1016/0014-2999(93)90414-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intravenous injection of big endothelin-3 (big ET-3, 1-41 amide) at 3 nmol/kg to ganglion-blocked anaesthetized rats produced a long-lasting hypertensive action, but the action was less potent than that seen with the same dose of ET-3-(1-21). The pressor effect induced by big ET-3 was markedly attenuated by pretreatment with phosphoramidon, 5 mg/kg i.v., a dose which had no effect on the hypertensive action induced by ET-3. These results strongly suggest that big ET-3 is converted to mature ET-3 by a phosphoramidon-sensitive metalloproteinase in vivo, in a manner similar to the conversion of big ET-1 to ET-1.

引用

页码：89 / 93

页数：5

共 16 条

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