SERUM IMMUNOGLOBULIN CONCENTRATIONS IN DIABETIC-PATIENTS

被引：37

作者：

ARDAWI, MSM

NASRAT, HAN

BAHNASSY, AA

机构：

[1] Department of Clinical Biochemistry, College of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah

[2] Department of Obstetrics and Gynaecology, College of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah

[3] Department of Community Medicine, College of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah

来源：

DIABETIC MEDICINE | 1994年 / 11卷 / 04期

关键词：

SERUM IGA; IGG; IGM; DIABETES-MELLITUS; GLYCATED HEMOGLOBIN;

D O I：

10.1111/j.1464-5491.1994.tb00290.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The relationship between glycated haemoglobin (an index of long-term diabetic control), fructosamine (an index of intermediate-term diabetic control), and serum IgA, IgG, and IgM was studied in 110 diabetic patients (41 Type 1 and 69 Type 2) and compared with 111 healthy non-diabetic subjects. Significant increases in serum IgA (by 82.7%, p < 0.001) and IgG (by 35.2%, p < 0.001) concentrations were observed whereas the concentration of IgM was significantly decreased (by 46.7%, p < 0.001) in diabetic patients compared with non-diabetic subjects. Using Spearman's rank correlations, IgA correlated with fructosamine (r = 0.77, p < 0.001), HbA, (r = 0.76, p < 0.001), and albumin (r = -0.58, p < 0.001) for the entire population sample but only fructosamine (r = 0.19, p < 0.05) and HbA, (r = 0.28, p < 0.001) correlated with IgA in diabetic patients, respectively. It is concluded that abnormal levels of IgA, IgG, and IgM are very common in diabetic patients in whom serum IgA concentrations are influenced by the degree of glycaemic control. Whether changes in IgA and other immunoglobulins are implicated in the pathogenesis of diabetic complications (such as susceptibility to infection) deserve further study.

引用

页码：384 / 387

页数：4

共 24 条

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