CASTANOSPERMINE AND OTHER POLYHYDROXY ALKALOIDS AS INHIBITORS OF INSECT GLYCOSIDASES

被引：29

作者：

SCOFIELD, AM ^{[1
]}

WITHAM, P ^{[1
]}

NASH, RJ ^{[1
]}

KITE, GC ^{[1
]}

FELLOWS, LE ^{[1
]}

机构：

[1] ROYAL BOT GARDENS, JODRELL LAB, RICHMOND TW9 3DS, SURREY, ENGLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY | 1995年 / 112卷 / 01期

关键词：

ALKALOID; CASTANOSPERMINE; DISACCHARIDASE; GLYCOSIDASE; INHIBITOR; INSECT; ISOMALTASE; POLYHYDROXYALKALOID; SWAINSONINE;

D O I：

10.1016/0300-9629(95)00070-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inhibition of glycosidase activity by a range of polyhydroxy alkaloids was studied in a number of insect species from the orders Orthoptera, Phasmida, Dictyoptera, Diptera and Coleoptera. Glycosidase activity was inhibited by a number of the alkaloids and the pattern of inhibition of hydrolysis of beta-glucosides and most alpha-glucosides (except trehalose) was different from that in mammals, 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine inhibited both alpha-glucosidase, including trehalase, and beta-glucosidase activity strongly in insects while castanospermine was a significant inhibitor only of beta-glucosidase activity, trehalase and in the Tenebrionidae, isomaltase and additionally, maltase in Zophobas morio. The identification of an isomaltase in the Tenebrionidae illustrates the value of the alkaloids as taxonomic tools.

引用

页码：187 / 196

页数：10

共 45 条

[1]

Applebaum S.W., 1985, P279

[2] PROPERTIES OF GLYCOSIDASES FROM THE MAIZE WEEVIL, SITOPHILUS-ZEAMAIS [J].

BAKER, JE .

INSECT BIOCHEMISTRY, 1991, 21 (06) :615-621

[3] DIFFERENTIAL INHIBITION BY CASTANOSPERMINE OF VARIOUS INSECT DISACCHARIDASES [J].

CAMPBELL, BC ;

MOLYNEUX, RJ ;

JONES, KC .

JOURNAL OF CHEMICAL ECOLOGY, 1987, 13 (07) :1759-1770

[4] SURVEY AND ELECTROPHORETICAL SEPARATION OF THE GLYCOSIDASES OF RHAGIUM-INQUISITOR (COLEOPTERA, CERAMBYCIDAE) LARVAE [J].

CHIPOULET, JM ;

CHARARAS, C .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1985, 80 (02) :241-246

[5] ASSAY OF INTESTINAL DISACCHARIDASES [J].

DAHLQVIST, A .

ANALYTICAL BIOCHEMISTRY, 1968, 22 (01) :99-+

[6] THE STORAGE PRODUCTS IN GENETIC AND SWAINSONINE-INDUCED HUMAN MANNOSIDOSIS [J].

DIBELLO, IC ;

DORLING, P ;

WINCHESTER, B .

BIOCHEMICAL JOURNAL, 1983, 215 (03) :693-696

[7]

DUVE H, 1972, INSECT BIOCHEM, V2, P445

[8]

EVANS SV, 1985, ENTOMOL EXP APPL, V37, P257, DOI 10.1007/BF00191657

[9]

FELLOWS LE, 1989, SWAINSONINE AND RELATED GLYCOSIDASE INHIBITORS, P396

[10]

FELLOWS LE, 1992, PR PHYT SOC, V33, P271

← 1 2 3 4 5 →