THE HUMAN SEROTONIN 5-HYDROXYTRYPTAMINE(1D) RECEPTOR PSEUDOGENE IS TRANSCRIBED

被引:19
作者
BARD, JA
NAWOSCHIK, SP
ODOWD, BF
GEORGE, SR
BRANCHEK, TA
WEINSHANK, RL
机构
[1] SYNAPT PHARMACEUT CORP,PARAMUS,NJ 07652
[2] ADDICT RES FDN,TORONTO,ON M5S 2S1,CANADA
关键词
G-PROTEIN-COUPLED RECEPTOR; ALU SEQUENCE; AFRICAN GREEN MONKEY; POLYMERASE CHAIN REACTION;
D O I
10.1016/0378-1119(94)00693-M
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
An examination of mRNA expression of the serotonin genes encoding both psi 5HT(1D alpha) and the related 5HT(1D alpha), demonstrated that the pseudogene is transcribed, and has a tissue distribution similar to the 5HT(1D alpha) receptor-encoding gene. This psi 5HT(1D alpha) transcript is capable of being translated into a polypeptide of only 28 amino acids in length, and the psi 5HT(1D alpha) pseudogene most likely arose from a gene duplication or transposition event.
引用
收藏
页码:295 / 296
页数:2
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