MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC-ACIDOSIS, AND STROKE-LIKE EPISODES (MELAS) - CURRENT CONCEPTS

被引：251

作者：

HIRANO, M

PAVLAKIS, SG

机构：

[1] COLUMBIA PRESBYTERIAN MED CTR,DEPT NEUROL,NEW YORK,NY 10032

[2] CORNELL UNIV,COLL MED,DEPT NEUROL,NEW YORK,NY

[3] CORNELL UNIV,COLL MED,DEPT PEDIAT,NEW YORK,NY

来源：

JOURNAL OF CHILD NEUROLOGY | 1994年 / 9卷 / 01期

关键词：

D O I：

10.1177/088307389400900102

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS) syndrome is one of many mitochondrially inherited multisystem diseases. The features of 110 reported mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes patients are reviewed to define the clinical spectrum of this disease. The clinical disorder, in addition to emerging concepts of genetic etiology, is promoting our understanding of mitochondrial functions. New knowledge may lead to more rational therapies. Finally, the recent revolution in the study of mitochondrial diseases may further our understanding of other degenerative disorders and even aging.

引用

页码：4 / 13

页数：10

共 124 条

[1] FLUCTUATING MR IMAGES WITH MITOCHONDRIAL ENCEPHALOPATHY, LACTIC-ACIDOSIS, STROKE-LIKE SYNDROME (MELAS) [J].