STRICTLY MATERNAL INHERITANCE OF RAT MITOCHONDRIAL-DNA

被引：78

作者：

HAYASHI, JI

YONEKAWA, H

GOTOH, O

WATANABE, J

TAGASHIRA, Y

机构：

[1] Biochemistry Division, Saitama Cancer Center Research Institute, Saitama, 362, Ina-machi

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 83卷 / 03期

关键词：

D O I：

10.1016/0006-291X(78)91499-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maternal inheritance of rat mitochondrial DNA (mtDNA) was demonstrated in Sprague-Dawley rats, which have two types of mtDNAs with respect to their EcoRI cleavage patterns on agarose gel electrophoresis. Use of litters of rats with the two types of mtDNAs for interbreeding showed that the mtDNA type of the progeny was the same as that of the dam. Furthermore, examination using the electrophoresis system that can detect as little as 0.02 μg mtDNA showed that 237 progeny in at least 40 generations in the closed breeding colony had one or other type of mtDNA, but that no individual had both types. Thus it is concluded that maternal inheritance of rat mtDNA is strict. © 1978.

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页码：1032 / 1038

页数：7

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