DRUG TEST CHAMBER - A TITANIUM IMPLANT FOR ADMINISTRATION OF BIOCHEMICAL AGENTS TO A STANDARDIZED BONE CALLUS INSITU

被引:13
作者
ASPENBERG, P
ALBREKTSSON, T
LOHMANDER, LS
THORNGREN, KG
机构
[1] GOTHENBURG UNIV,DEPT HANDICAP RES,S-41124 GOTHENBURG,SWEDEN
[2] GOTHENBURG UNIV,DEPT ANAT,EXPTL BIOL LAB,S-41124 GOTHENBURG,SWEDEN
来源
JOURNAL OF BIOMEDICAL ENGINEERING | 1988年 / 10卷 / 01期
关键词
BIOLOGICAL MATERIALS - Bone - BIOMEDICAL ENGINEERING - Surgical Implants - TITANIUM AND ALLOYS - Biocompatibility;
D O I
10.1016/0141-5425(88)90029-5
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A titanium implant in which a conduit is gradually filled with ingrowing bone (the Bone Harvest Chamber) has been modified to allow continuous local treatment of the conduit tissue with biochemical agents. Implants were inserted bilaterally in rabbit tibiae. The tissue content of the bone ingrowth conduits was studied with histology, **9**9**mTc-MDP scintimetry and measurements of total calcium content. The collagen of the harvested tissue from the **3H-proline treated side had a **3H-hydroxyproline content 1000 times greater than had the control side. The 'drug test chamber' makes possible the study of local effects of drugs on healing of mature bone in vivo.
引用
收藏
页码:70 / 73
页数:4
相关论文
共 12 条
[1]  
ALBREKTSSON T, 1985, Critical Reviews in Biocompatibility, V1, P53
[2]   THE INTERFACE ZONE OF INORGANIC IMPLANTS INVIVO - TITANIUM IMPLANTS IN BONE [J].
ALBREKTSSON, T ;
BRANEMARK, PI ;
HANSSON, HA ;
KASEMO, B ;
LARSSON, K ;
LUNDSTROM, I ;
MCQUEEN, DH ;
SKALAK, R .
ANNALS OF BIOMEDICAL ENGINEERING, 1983, 11 (01) :1-27
[3]  
ALBREKTSSON T, 1984, BIOMATERIALS BIOMECH, P283
[4]  
CANALIS E, 1985, CLIN ORTHOP RELAT R, V193, P246
[5]  
COSSAR JM, 1974, ANN CLIN BIOCHEM, V2, P18
[6]   GROWTH-HORMONE STIMULATES LONGITUDINAL BONE-GROWTH DIRECTLY [J].
ISAKSSON, OGP ;
JANSSON, JO ;
GAUSE, IAM .
SCIENCE, 1982, 216 (4551) :1237-1239
[7]  
JAKOBSSON M, 1985, THESIS GOTEBORG SWED
[8]  
LISTROM RD, 1984, THESIS TORONTO CANAD
[9]   INFLUENCE OF COLCHICINE ON SYNTHESIS AND SECRETION OF PROTEOGLYCANS AND COLLAGEN BY FETAL GUINEA-PIG CHONDROCYTES [J].
LOHMANDER, S ;
MOSKALEWSKI, S ;
MADSEN, K ;
THYBERG, J ;
FRIBERG, U .
EXPERIMENTAL CELL RESEARCH, 1976, 99 (02) :333-345
[10]  
RUSSEL RGG, 1976, BIOCH PHYSL BONE, P61