ACTION OF MIRACIL ON HUMAN LEUKOCYTE CHROMOSOMES IN VITRO

In human leukocyte chromosomes in vitro the thioxanthon derivative 1-(2-diethylaminoethylamino)-4-methylthioxanthone hydrochloride (Miracil D) induces especially achromatic lesions (AL) und chromatid breaks (B′). The frequencies of isochromatid breaks (B″) are at the control level, and chromatid translocations (RB′) are only found at the two highest concentrations tested. The results are compared with the findings of Lüers (1955) on the mutagenic action of the same substance in Drosophila and with the action of the monofunctional ethyleneimino compound 2-ethyleneimino-5.6.7.8.-tetrahydronaphtoquinone-1,4 (A 137) in Drosophila and human leukocyte chromosomes in vitro. A connection of AL with mutational events seems doubtful. © 1969 Springer-Verlag.