METABOLIC AND PATHOLOGICAL EFFECTS OF NICOTINE ON GASTROINTESTINAL-TRACT AND PANCREAS OF RATS

被引：49

作者：

CHOWDHURY, P

HOSOTANI, R

CHANG, L

RAYFORD, PL

机构：

[1] Departments of Physiology, University of Arkansas for Medical Sciences, Little Rock, AR

[2] Departments of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR

来源：

PANCREAS | 1990年 / 5卷 / 02期

关键词：

Alterations; Endocrine; Gastrointestinal dysfunction; Histopathologic; Metabolic; Nicotine withdrawal; Nicotine-Chronic effects;

D O I：

10.1097/00006676-199003000-00016

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We examined in male Sprague-Dawley rats the effects of nicotine at doses of 50 (0.31 mM) and 200 mg/L (1.23 mM) given for a period of 16 weeks on body weight gain, food and fluid intake, plasma CCK, glucose and insulin levels, amylase secretory responses of isolated pancreatic acinar cells to CCK-8 and carbachol, and histopathology (gross and light microscopy) of stomach and pancreas. These parameters were re-examined further in animals treated with nicotine at doses of 200 mg/L (1.23 mM) for 12 weeks and given tap water for an additional 4 weeks to evaluate the effects of nicotine withdrawal. Metabolic data suggest that decreases in body weight gain, food and fluid intake, and plasma levels of glucose and insulin by nicotine are dose dependent. Endocrinological studies showed that the plasma levels of CCK were significantly increased with nicotine but the amylase secretory response of pancreatic acinar cells was inhibited in response to CCK-8 and carbachol. Histopathologic data revealed that treatment of animals with a high dose of nicotine enhanced the appearance of numerous vacuoles in the pancreatic acinar cell cytoplasm. When the pancreatic acinar cell morphology was closely examined, it showed evidence of pyknotic nuclei and fusion of vacuoles. Prominent loss of gastric mucosal surface was found in nicotine-treated animals with gross microscopic evidence of bleeding ulcers. All of the metabolic parameters except body weight gain were reversed upon nicotine withdrawal. In addition, plasma CCK levels and pancreatic enzyme secretion were reversed upon nicotine withdrawal. Histopathologic data showed a partial but not a complete recovery of the pancreatic acinar cell morphology and gastric mucosal surface following 4 weeks of nicotine withdrawal. The data suggest that nicotine ingested chronically alters metabolic, endocrine, and pathologic factors that may be responsible, at least in part, for the development of gastrointestinal ulcers and pancreatitis. These alterations appear to have been substantially prevented by abstinence of nicotine ingestion. © 1990 Raven Press, Ltd., New York.

引用

页码：222 / 229

页数：8

共 47 条

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