REDUCTION IN TESTICULAR FUNCTION IN RATS .2. REDUCTION BY DEXAMETHASONE IN FETAL AND NEONATAL RATS

被引:45
作者
LALAU, JD
AUBERT, ML
CARMIGNAC, DF
GREGOIRE, I
DUPOUY, JP
机构
[1] UNIV LILLE 1,NEUROENDOCRINOL & DEV LAB,SN4,F-59655 VILLENEUVE DASCQ,FRANCE
[2] FAC SCI AMIENS,PHYSIOL ANIM LAB,AMIENS,FRANCE
[3] FAC MED GENEVA,DEPT PEDIAT,DIV BIOL CROISSANCE & REPROD,GENEVA,SWITZERLAND
关键词
Dexamethasone; Fetus; GnRH; LH; Neonate; Rat; Testosterone;
D O I
10.1159/000125352
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic administration of dexamethasone in drinking water to maternal rats from days 15 to 21 of gestation (1) reduced plasma testosterone concentrations in male fetuses between days 19 and 21 but not earlier on day 18 and abolished the prenatal peak of plasma testosterone which normally occurs on day 19 of gestation, and (2) suppressed the postnatal surge of plasma testosterone in male newborns 1.5 and 2 h after delivery at term by cesarean section. The administration of dexamethasone to male fetuses at birth induced 1 h later a slight but not significant increase in hypothalamic gonadotropin-releasing hormone (GnRH) and pituitary luteinizing hormone (LH) contents, reduced drastically plasma LH levels and completely prevented the postnatal surge of plasma testosterone which occurred normally in littermate controls. A rise in pituitary LH content, and a sharp reduction in plasma LH and testosterone concentrations were noted in 19-day-old male fetuses whose mothers were acutely treated with dexamethasone on day 18 of gestation. Similar evolutions for LH were observed in littermate females. These results suggest that the inhibitory effects of exogenous glucocorticoids on testosterone secretion could be mediated in both fetuses and newborns at least partially through suppression of the hypothalamic and pituitary secretion of GnRH and LH, respectively, and provide insight how stress or hormone imbalance may affect the development of this neuroendocrine system. © 1990 S. Karger AG, Basel.
引用
收藏
页码:289 / 293
页数:5
相关论文
共 30 条
[1]   EFFECTS OF DEXAMETHASONE ON LH-RELEASE AND OVULATION IN CYCLIC RAT [J].
BALDWIN, DM ;
SAWYER, CH .
ENDOCRINOLOGY, 1974, 94 (05) :1397-1403
[2]   EFFECT OF GLUCOCORTICOIDS ON ESTROGEN-DEPENDENT LUTEINIZING-HORMONE RELEASE IN THE OVARIECTOMIZED RAT AND ON GONADOTROPIN-SECRETION IN THE INTACT FEMALE RAT [J].
BALDWIN, DM .
ENDOCRINOLOGY, 1979, 105 (01) :120-128
[3]  
CORBIER P, 1981, CR ACAD SCI III-VIE, V292, P413
[4]   CHANGES IN TESTICULAR WEIGHT AND SERUM GONADOTROPIN AND TESTOSTERONE LEVELS BEFORE, DURING, AND AFTER BIRTH IN PERINATAL RAT [J].
CORBIER, P ;
KERDELHUE, B ;
PICON, R ;
ROFFI, J .
ENDOCRINOLOGY, 1978, 103 (06) :1985-1991
[5]  
CROBIER P, 1984, SEXUAL DIFFERENTIATI, P133
[6]   CORTISOL-INDUCED SUPPRESSION OF PLASMA TESTOSTERONE IN NORMAL ADULT MALES [J].
DOERR, P ;
PIRKE, KM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1976, 43 (03) :622-629
[7]   HETEROGENEITY OF ADRENOCORTICOTROPIN IN THE PITUITARY-GLAND AND PLASMA DURING THE PERINATAL-PERIOD [J].
DUPOUY, JP ;
CHATELAIN, A .
REPRODUCTION NUTRITION DEVELOPMENT, 1985, 25 (05) :945-961
[8]  
DUPOUY JP, 1981, J PHYSIOLOGY PARIS, V77, P955
[9]  
DUPOUY JP, 1987, BIOL NEONATE, V52, P216
[10]   EFFECTS OF ACUTE STRESS ON SERUM LH AND PROLACTIN IN INTACT, CASTRATE AND DEXAMETHASONE-TREATED MALE RATS [J].
EUKER, JS ;
MEITES, J ;
RIEGLE, GD .
ENDOCRINOLOGY, 1975, 96 (01) :85-92