EFFECTS OF CLONIDINE AND YOHIMBINE ON THE PUPILLARY LIGHT REFLEX AND CARBACHOL-EVOKED SWEATING IN HEALTHY-VOLUNTEERS

被引：26

作者：

MORLEY, MJ ^{[1
]}

BRADSHAW, CM ^{[1
]}

SZABADI, E ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT PSYCHIAT,STOPFORD BLDG,OXFORD RD,MANCHESTER M13 9PT,LANCS,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 31卷 / 01期

关键词：

CLONIDINE; YOHIMBINE; PUPILLARY LIGHT REFLEX; CARBACHOL-EVOKED SWEATING; ALPHA-2-ADRENOCEPTORS;

D O I：

10.1111/j.1365-2125.1991.tb03864.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of single doses of clonidine hydrochloride (200-mu-g), yohimbine hydrochloride (22 mg), a combination of the two treatments, and placebo, on some autonomic functions were studied in healthy volunteers using a double-blind crossover design. Clonidine prolonged the recovery time of the light reflex, lowered systolic blood pressure and reduced subjectively rated alertness; these effects were reversed by yohimbine. Responsiveness of sweat glands to carbachol was not affected by the treatments.

引用

页码：99 / 101

页数：3

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