INHIBITION OF CALCIUM-OXALATE CRYSTALLIZATION BY URINARY MACROMOLECULES

被引:12
作者
BEKJENSEN, H [1 ]
TISELIUS, HG [1 ]
机构
[1] LINKOPING UNIV HOSP,DEPT UROL,S-58185 LINKOPING,SWEDEN
来源
UROLOGICAL RESEARCH | 1991年 / 19卷 / 03期
关键词
AP (CAOX) INDEX; CALCIUM OXALATE; DIALYZED URINE; URINARY MACROMOLECULES;
D O I
10.1007/BF00303743
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The crystallization of calcium oxalate (CaOx) was determined in dialyzed urine samples collected between 0600 and 1000 hours from 18 normal men, 10 normal women and 13 men and 10 women with CaOx stone disease. Each urine samples was supersaturated by the addition of calcium chloride and sodium oxalate, and CaOx crystallization was followed by quantification of the [C-14]-oxalate remaining in solution for 30 min after supersaturation of the sample. The rate of crystallization was compared with that in physiological saline. The surface area delimited by the urine and saline curves was used to express the inhibition of CaOx crystallization by urinary macromolecules (I(UMM)). The I(UMM) was significantly higher in urine from normal women than in that from stone-forming women (P < 0.05), normal men (P < 0.005), and stone-forming men (P < 0.02). However, there were no significant differences between stone-forming men and stone-forming women, nor was I(UMM) higher in normal men than in stone-forming men. A high concentration of inhibitors might protect women from CaOx stone formation and be one factor explaining the lower stone-formation rate in women. Although low values were more predominate in normal men than in normal women, there were no significant differences between the groups when the inhibition was corrected for differences in urinary volumes.
引用
收藏
页码:165 / 169
页数:5
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