POLYSIALIC ACIDS - POTENTIAL IN DRUG DELIVERY

被引：76

作者：

GREGORIADIS, G ^{[1
]}

MCCORMACK, B ^{[1
]}

WANG, Z ^{[1
]}

LIFELY, R ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

FEBS LETTERS | 1993年 / 315卷 / 03期

关键词：

POLYSACCHARIDE; POLYSIALIC ACID; DRUG DELIVERY SYSTEM; DRUG TARGETING; DRUG CLEARANCE;

D O I：

10.1016/0014-5793(93)81177-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of bacterial polysialic acids were injected intravenously into mice. Half-lives (up to 40 h) in the blood circulation were dependent on the polysialic acid used, increased by deacylation of their phospholipid moiety, decreased with shorter chain derivatives and appeared to be dose independent. A model drug (fluorescein) covalently coupled to a polysialic acid was found to assume the half-life of its carrier. Results suggest that intact or deacylated polysialic acids and shorter chain derivatives can be used to augment the half-lives of drugs, small peptides, proteins and drug delivery systems in the blood circulation, thus prolonging their pharmacological action.

引用

页码：271 / 276

页数：6

共 26 条

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