LINKAGE MAPPING OF THE AML1 GENE ON HUMAN CHROMOSOME-21 USING A DNA POLYMORPHISM IN THE 3' UNTRANSLATED REGION

被引：7

作者：

AVRAMOPOULOS, D

COX, T

BLASCHAK, JE

CHAKRAVARTI, A

ANTONARAKIS, SE

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,CTR MED GENET,DEPT PEDIAT & MED,BALTIMORE,MD 21205

[2] UNIV PITTSBURGH,DEPT PSYCHIAT,PITTSBURGH,PA 15261

[3] UNIV PITTSBURGH,DEPT HUMAN GENET,PITTSBURGH,PA 15261

来源：

GENOMICS | 1992年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0888-7543(05)80253-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have detected a polymorphism in the 3′ untranslated region of the AML1 gene, which is located at the breakpoint on chromosome 21 in the t(8;21)(q22;q22.3) translocation often associated with patients with acute myeloid leukemia. Informative CEPH families were genotyped for this polymorphism and used to localize the gene on the linkage map of human chromosome 21. The AML1 gene is located between the markers D21S216 and D21S211, in chromosomal band 21q22.3. © 1992 Academic Press, Inc. All rights reserved.

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页码：506 / 507

页数：2

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