STABILITY-INDICATING DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF FRUSEMIDE

被引：6

作者：

ABDELHAY, MH ^{[1
]}

机构：

[1] UNIV ALEXANDRIA,FAC PHARM,DEPT PHARMACEUT ANALYT CHEM,ALEXANDRIA,EGYPT

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 99卷 / 2-3期

关键词：

FRUSEMIDE DETERMINATION; DEGRADATION PRODUCT; DERIVATIVE SPECTROPHOTOMETRY; KINETICS; DOSAGE FORM;

D O I：

10.1016/0378-5173(93)90377-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The development of a first- and second-derivative spectrophotometric determination of frusemide in pharmaceutical formulations in the presence of its acid-hydrolysis product 'saluamine', is described. The procedure involves measurements of first-derivative amplitudes at 254 and 262 nm (1D254 and 1D262) and second-derivative amplitudes at 265 and 272 nm (2D265 and 2D272) for the assay of frusemide and saluamine, respectively. Kinetic investigation of the acid degradation rate of frusemide revealed that the proposed method is stability indicating. Tablets and injections have been assayed and the results indicated that the proposed derivative spectrophotometric method is as accurate and precise as the official method.

引用

页码：333 / 336

页数：4

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