THYROID-FUNCTION IN CHILDREN WITH NEPHROTIC SYNDROME

被引：73

作者：

ITO, S ^{[1
]}

KANO, K ^{[1
]}

ANDO, T ^{[1
]}

ICHIMURA, T ^{[1
]}

机构：

[1] DOKKYO UNIV,SCH MED,DEPT PAEDIAT 1,MIBU,TOCHIGI 32102,JAPAN

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 04期

关键词：

THYROID FUNCTION; NEPHROTIC SYNDROME; FREE THYROXINE; FREE TRIIODOTHYRONINE; URINARY THYROID HORMONES;

D O I：

10.1007/BF00856516

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The thyroid function of seven children with untreated nephrotic syndrome who had a normal serum creatinine concentration was compared with that of the same patients in remission and age-matched controls. There was a significant decrease in serum thyroxine (T-4), tri-iodothyronine (T-3) and thyroid-binding globulin (TBG) concentrations in untreated nephrotic children compared with the same patients in remission and age-matched controls. Most values for serum free T-4, free T-3 and thyroid-stimulating hormone (TSH) in the patients with nephrosis were within the normal range. However, the mean serum free T-4 and free T-3 concentrations were significantly (P < 0.05) lower in the untreated patients than in the same patients in remission, and the mean serum TSH concentrations were significantly (P < 0.05) higher in the untreated patients than in the same patients in remission. There were massive urinary losses of T-4, T-3, TBG, free T-4 and free T-3 in the untreated nephrotic children compared with the same patients in remission and age-matched controls. The daily urinary protein excretion showed a positive correlation with the urinary T-4, T-3, free T-4, free T-3 and TBG excretion. Furthermore, the urinary protein excretion showed a negative correlation with the serum T-4, T-3, free T-4, free T-3 and TBG levels. There was a negative correlation between serum albumin and serum TSH. These findings provide evidence of mild hypothyroidism in children with untreated nephrotic syndrome, partly because of losses of T-4, T-3, free T-4, free T-3 and TBG into the urine.

引用

页码：412 / 415

页数：4

共 20 条

[1]

Gavin L.A., McMahon F.A., Castle J.N., Cavafieri R.R., Alterations in serum thyroid hormones and thyroxine-binding globulin in patients with nephrosis, J Clin Endocrinol Metab, 46, pp. 125-130, (1978)

[2]

Adlkofer F., Hain H., Meinhold H., Kraft D., Raden D., Herrmann J., Heller W.D., Tyhroid function in patients with proteinuria and normal or increased serum creatinine concentration, Acta Endocrinol (Copenh), 102, pp. 367-376, (1983)

[3]

Afrasiabi M.A., Vaziri N.D., Gwinup G., Mays D.M., Barton C.H., Ness R.L., Valenta L.J., Thyroid function studies in the nephrotic syndrome, Ann Intern Med, 90, pp. 335-338, (1979)

[4]

DeLuca F., Gamelli M., Pandullo E., Barberio G., Benvenga S., Trimarchi F., Changes in thyroid function tests in infantile nephrotic syndrome, Horm Metabo Res, 15, pp. 258-259, (1983)

[5]

Liappis N., Rao G.S., Verhalten der Konzentration von freiem Trijodthyronin, Trijodthyronin, freiem Thyroxin, Thyroxin, Thyreotropin und thyroxinbindendem Globulin im Serum von Kindern mit nephrotischem Syndrom, Klin Pediatr, 197, pp. 423-426, (1985)

[6]

Etling N., Fouque F., Effect of prednisone on serum and urinary thyroid hormone levels in children during the nephrotic syndrome, Helv Paediatr Acta, 37, pp. 257-265, (1982)

[7]

McLean R.H., Kennedy T.L., Rosoulpour M., Ratzan S.K., Siegel N.J., Kauschansky A., Genel M., Hypothyroidism in the congenital nephrotic syndrome, J Pediatr, 101, pp. 72-75, (1982)

[8]

Warydy B.A., Howard C.P., Hellerstein S., Alon U., Grune J.A., Congenital nephrosis in association with hypothyroidism and hypoadrenocortism, Pediatric Nephrology, 7, pp. 79-80, (1993)

[9]

Kano K., Hagane M., Ito S., Ichimura T., Thyroid therapy for a boy with nephrotic syndrome, J Jpn Pediatr Soc, 97, (1993)

[10]

Nicoloff J.T., Fisher D.A., Appleman M.D., The role of glucocorticoids in the regulation of thyroid function in man, J Clin Invest, 49, pp. 1922-1929, (1970)

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