IDENTIFICATION OF URINARY METABOLITES OF FLAVANONE IN THE RAT

被引：12

作者：

BUSET, H

SCHELINE, RR

机构：

[1] Department of Pharmacology, School of Medicine, University of Bergen, Haukeland Sykehus, Bergen

[2] Environmental Technology Section, Applied Chemistry Division, Foundation of Scientific and Industrial Research, University of Trondheim, Trondheim

来源：

BIOMEDICAL MASS SPECTROMETRY | 1979年 / 6卷 / 05期

关键词：

D O I：

10.1002/bms.1200060509

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The urinary metabolites of flavanone in the rat were investigated using a gas chromatographic mass spectrometric method employing an OV‐1 capillary column. Forty‐three metabolites were detected and the most prominent of these were identified. The most common metabolic reactions were reduction of the keto group and hydroxylation at the 3‐ or 6‐positions. Little hydroxylation occurred in ring B. The major metabolites were flavan‐4α‐ol, trans‐3‐hydroxyflavan‐4β‐ol, 6‐hydroxyflavanone and 6‐hydroxyflavan‐4β‐ol. Gas chromatographic analysis of underivatized flavanone metabolites, especially with stainless steel columns, results in the formation of dehydrated products including flavone, flav‐3‐ene and flavanone itself. Copyright © 1979 Heyden & Son Ltd

引用

页码：212 / 220

页数：9

共 18 条

[1] CONFIGURATION OF FLAVAN-4-OLS [J].