RENAL CONSEQUENCES OF IMMOBILIZATION IN CHILDREN WITH FRACTURED FEMURS

Parameters of renal function and calcium homeostasis were studied in 8 children, immobilised for 5-9 weeks with fractured femurs, weekly during immobilisation and fourth weekly following mobilisation until all parameters returned to normal. During immobilisation 1 patient became hypercalcaemic, but all showed an increase in serum calcium and all developed hypercalciuria. During immobilisation all showed diminished urine osmolality after a 12-hour fast (mean 591 ± 133 mOsm/kg) which improved 4-39 weeks after mobilisation (mean 973 ± 87 mOsm/kg). Serum creatinine, urinary beta-2-microglobulin and renal ultrasound appearances were all normal. An inverse relationship, R = -0.70, was demonstrated between serum calcium and fasting urine osmolality during immobilisation. Three patients showed diminished urinary concentrating ability beyond 4 weeks after mobilisation. For 1 patient this defect persisted for 8 months and glomerular filtation rate was diminished 9 months after mobilisation, raising the possibility of long term renal damage in immobilised patients.