POTENTIAL ANTI-TUMOR AGENTS .8. CYTOTOXIC CARDENOLIDE FROM CORONILLA-VARIA

被引：25

作者：

HEMBREE, JA ^{[1
]}

CHANG, CJ ^{[1
]}

MCLAUGHLIN, JL ^{[1
]}

PECK, G ^{[1
]}

CASSADY, JM ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARM SCI,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

JOURNAL OF NATURAL PRODUCTS | 1979年 / 42卷 / 03期

关键词：

D O I：

10.1021/np50003a009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Hyrcanoside has been previously isolated as a cytotoxic and antitumor cardenolide of the seeds of Coronilla varia L. (crown vetch). Reextractions detected cytotoxic activity attributable to another cardenolide which was isolated and crystallized after repeated chromatographic manipulations. Spectral analyses (pmr, 13C nmr, and ms) suggested that the compound was deglucohyrcanoside. Partial enzymatic hydrolysis of hyrcanoside provided reference compound which was identical (tic, ms). © 1979, American Chemical Society. All rights reserved.

引用

页码：293 / 298

页数：6

共 22 条

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