BIOCHEMICAL MARKERS OF COMPLIANCE IN THE PHYSICIANS HEALTH STUDY

被引：31

作者：

SATTERFIELD, S ^{[1
]}

GRECO, PJ ^{[1
]}

GOLDHABER, SZ ^{[1
]}

STAMPFER, MJ ^{[1
]}

SWARTZ, SL ^{[1
]}

STEIN, EA ^{[1
]}

KAPLAN, L ^{[1
]}

HENNEKENS, CH ^{[1
]}

机构：

[1] BRIGHAM & WOMENS HOSP,DEPT MED,CHANNING LAB,BOSTON,MA 02115

来源：

AMERICAN JOURNAL OF PREVENTIVE MEDICINE | 1990年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0749-3797(18)30997-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The Physicians' Health Study is a randomized, double-blind, placebo-controlled trial using a 2 X 2 factorial design to test the effects of low-dose aspirin on risk of cardiovascular disease and beta-carotene supplementation on the incidence of cancer. To evaluate self-reported compliance with assigned treatment, we measured serum thromboxane B2, which is decreased after aspirin use, and plasma beta-carotene in samples of study participants drawn from three geographic locations in three different time periods. Thromboxane B2 levels were markedly lower in those assigned to aspirin (median = 63.5 pg/mL) than in those given aspirin placebo (median = 3,600 pg/mL, P < .0001). Similarly, those assigned to beta-carotene had significantly higher levels (median = 1,176 ng/mL) than those given placebo (median = 306 ng/mL, P < .0001). In addition, there was a highly significant positive correlation between levels of these biochemical markers and the self-reports of compliance (tau = 0.65 for thromboxane B2 and tau = 0.69 for beta-carotene, P < .0001). These findings support the validity of the self-reported compliance in the Physicians' Health Study.

引用

页码：290 / 294

页数：5