EVIDENCE FOR THE REGULATION OF 3-BETA-HYDROXYSTEROID DEHYDROGENASE MESSENGER-RNA BY HUMAN CHORIONIC-GONADOTROPIN IN LUTEINIZED PORCINE GRANULOSA-CELLS

被引：46

作者：

CHEDRESE, PJ

THE, VL

LABRIE, F

JUORIO, AV

MURPHY, BD

机构：

[1] UNIV SASKATCHEWAN,REPROD BIOL RES UNIT,SASKATOON S7N 0W0,SASKATCHEWAN,CANADA

[2] UNIV SASKATCHEWAN,NEUROPSYCHIAT RES UNIT,SASKATOON S7N 0W0,SASKATCHEWAN,CANADA

[3] CHU LAVAL,RES CTR,DEPT MOLEC ENDOCRINOL,QUEBEC CITY G1V 4G2,QUEBEC,CANADA

来源：

ENDOCRINOLOGY | 1990年 / 126卷 / 04期

关键词：

D O I：

10.1210/endo-126-4-2228

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of hCG on the abundance of messenger RNA for the steroidogenic enzyme 3β-hydroxysteroid dehydrogenase (3β-OHSD) were studied in luteinized porcine granulosa cells. There were dose-dependent increases in the mRNA for this enzyme after 8 h incubation with hCG or dibutyryl cAMP. The results suggest that LH-like hormones regulate the expression of the 3β-OHSD gene in luteinized tissue, and this genomic regulation is a component of the luteotrophic regulation of steroidogenesis in the ovary. © 1990 by The Endocrine Society.

引用

页码：2228 / 2230

页数：3

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