PERIPHERAL GLUCOSE-UPTAKE AND SKELETAL-MUSCLE GLUT4 CONTENT IN MAN - EFFECT OF INSULIN AND FREE FATTY-ACIDS

被引：15

作者：

HANDBERG, A

VAAG, A

BECKNIELSEN, H

VINTEN, J

机构：

[1] Institute of Medical Physiology B, Panum Institute, Copenhagen

[2] Department of Endocrinology, University Hospital of Odense, Odense

来源：

DIABETIC MEDICINE | 1992年 / 9卷 / 07期

关键词：

EUGLYCEMIC HYPERINSULINEMIC CLAMP; GLUCOSE TRANSPORTER; MUSCLE ADIPOSE TISSUE; GLUCOSE UPTAKE; LIPID INFUSION;

D O I：

10.1111/j.1464-5491.1992.tb01854.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate the relationship between glucose uptake and the content of the insulin regulatable glucose transporter, GLUT4, in skeletal muscle at near physiological insulin concentrations in vivo, we measured the effect of a 3h euglycemic insulin-infusion (40 mU m-2 min-1) on glucose uptake and skeletal muscle GLUT4 content in lo healthy subjects. We found no correlation (r almost-equal-to 0.1) between individual muscle GLUT4 content and insulin-stimulated glucose uptake. Mean GLUT4 content in skeletal muscle was reduced by 19 +/- 6.3 % (mean +/- SE, p < 0.02) after insulin infusion. However, when the same subjects were made insulin resistant by infusion of lipid, as evidenced by a reduction of 16 +/- 7.2 % (mean +/- SE, p < 0.05), in insulin-stimulated glucose uptake, the effect of insulin on GLUT4 content was attenuated and no change in GLUT4 content was observed. Our results show that the total content of skeletal muscle GLUT4 is a poor predictor for in vivo response to near physiological insulin concentrations in healthy human subjects.

引用

页码：605 / 610

页数：6

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