RELATION BETWEEN PLASMA-CONCENTRATION AND CLINICAL EFFICACY AFTER SUBLINGUAL SINGLE DOSE APOMORPHINE IN PARKINSONS-DISEASE

被引：17

作者：

DURIF, F

JEANNEAU, E

SERREDEBEAUVAIS, F

DEFFOND, D

ESCHALIER, A

TOURNILHAC, M

机构：

[1] CHU CLERMONT FERRAND,NEUROL CLIN,F-63003 CLERMONT FERRAND,FRANCE

[2] CHU CLERMONT FERRAND,SERV PHARMACOL,F-63003 CLERMONT FERRAND,FRANCE

[3] CHU GRENOBLE,SERV PHARMACOL,F-38043 GRENOBLE,FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 41卷 / 05期

关键词：

PARKINSONS DISEASE; APOMORPHINE; PHARMACOKINETICS; ADVERSE EFFECT; ON-OFF EFFECT;

D O I：

10.1007/BF00626377

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.

引用

页码：493 / 494

页数：2

共 8 条

[1] DETERMINATION OF APOMORPHINE IN RAT PLASMA AND BRAIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION [J].